GVK BIO extensive experience In PK Services

Information about GVK BIO extensive experience In PK Services

Published on August 1, 2014

Author: gvk_bio

Source: authorstream.com

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PowerPoint Presentation: P K Se rvic e s A n im a l F ac i l i t y GV K BIO v iv arium i s A AA LA C ce rt i f i e d and re gis t ered w i th C P C SE A ( C o m m i t t e e f or t h e Pu r p ose of Control and Su p e rv i s i on of Ex p e r i men ts on An i m a l s) , G o v ern m ent o f I n d i a . In our rod en t f a c i l i ti e s , a n i ma l s are hou s ed i n I n d i v i d ua l Vent il at e d Cages (I VC) i n c ontro ll ed te m p e r a t u r e (22 ° - 25 ° C ) & re l at i v e hu mi d i ty ( 30% - 70%) m a i nt ai ned at 12 h/ 1 2 h li g h t/dark cy c l e. In Viv o P h a r m aco k in e t i c s Rats of d i f f e r en t stra i n s- S prag ue Daw l e y (SD), W i s t a r, Wi s t a r H an and Lew i s M i ce of d i f f e r en t stra i ns - S w i s s a l b i n o, B ALB /c, C57 B L/ 6 , C D -1, Nude m i c e , et c. H a m s t e r and G u i nea p i g s D i sc r e t e / Se r i a l / D r u g- D r u g I nt era ct i on R a p i d PK / S nap s h ot PK / C a ss e tte PK Ab s o l ute B i o av a il a b il i ty C apa b il i t i e s to c ond u c t PK / P D re l at i on s h i p s t u d i es B l o od s a m p l e c o l l ect i on t ec h n i q u e s – r e t r o - o r b i t a l / c a r d i a c p uncture/ t ail v ei n an d j u gular v e i n I n V i v o B l ood B r a i n B ar r i er ( BBB ) s t u dy T i ss u e D i s t r i b u t i on s t ud i es S p e c i a l i z ed s tu d i e s f o r e n teroh e pat i c / f i r s t pa s s e f f ect E x v i v o pro t e i n b i nd i n g s t u d i es to mea s u r e f r ee / b o un d drug and unbound d r u g i n p l a s m a, br a i n and C S F E x v i vo t i ss u e pe rme ab i li ty s t ud i e s - F r an z D i f f u s i on a ss a y ( P e r m e G e a r ) B il i ary e x c r e t i o n s t u d i es To x i c ok i net i c s t u d i es Pe r f u s i on c a p a b il i t i es Cann u l a t i o n / S u r gi c a l P r o c e d u re s J ugu l ar v e i n c annu l at i on P ort a l v e i n c ann u l at i on Bil e d uc t c ann u l at i on F em or a l v e i n c annu l at i on D o u b l e c ann u l at i on (jugu l ar and f e m ora l ) D o u b l e c annu l at i on (jugu l ar and port a l , j ugu l ar and b i l e du c t C arot i d artery c annu l at i on O v are ct o m y A dren a l e c t o m y Rou t es o f Admi nis t r a tio n Oral - S o l ut i o n , S u s p e n s i on , S o li d s ( pe l l e ts, c a psu l e s ) I n trav enous - Bo l u s , I n f us i on In t ra p e r i to n e al S ub c u t a n eou s I n tra m u sc u l ar Dermal I n tratrac heal Bu cc a l / Sub l i ngual I ntraduodenal I n trac o l on i c I ntrana sal T y p e o f P K S t u d i es S i ng l e D o s e Mu lti p l e D o se D ose L i nearity T i ss u e D i s t r i b u ti on A l t erna te D o s i n g D r u g - D r u g I n t era ct i on S t u d i e s F e d / F a st PK BBB BB B & CSF To p i c a l PK I n f us i on S t u d i e s C a ss e tte PK B i o l o g i ca l F l u i d/ Or g a n C o l l e c t i o n B l ood U r i ne C S F ( R a t ) BAL Bile Al l o rg an s ( b r a i n , l ung s, hea r t, l ym phno d e , s a l i v a ry gl a n d , o v a ry, s p l ee n, sk i n , m u s c l e, ad r e n a l s, k i d ne y, f at t i ss ue , t h ym u s e tc.) W e pro v i de f l ex i b i l i ty i n pr ot oc o l de v e l op m ent, q ua l i ty data and rap i d t urnarou nd t im e to our cli ent s. PowerPoint Presentation: A UC ( n g . h r /g ) C o n c e n t r a t i o n ( n g / m L ) A d r e n al … B l oo d B r a i n H ea r t Fa t L un g L i v er Ki dn e y L y m ph S a l i v a r y P a n c r eas T e s t i s M u scl e Sp l e en P K Se rvic e s Bi o- a n a l y s is An a l y s i s by LC - M S / MS /H P L C - U V / P D A / F l u or i me t ry / Sp e c trophoto m et e r M et h od De v e l op m ent and Va l i d at i o n i n B i o l o g i c a l M at ri c e s s u c h as B l ood, P l a sm a/ Se r u m , C S F and T i ss u e ho m oge n at es P K a n a l ys i s by W at s o n LIMS Q u a n t i f i c a t i o n o f P a r en t a nd Me ta b o l it e s , C as s et te A na l y sis , C e l l Cu l t u re M ea s ure m ent of P a r en t and P rod r u g T y p i c a l s t u d y de si g n f o r In V i v o P K / Bio - a na l y sis Re port d e l i v e r y w i t h i n s e v e n wor ki ng d ays A ni m al A d m in i st r a tion R out e P r oto c o l Para m ete rs D at a A n al y si s Blood/T i ss u e s a m ple s c ollec t e d a t sched u le d t i m e poi n t s po st do s in g , p las m a s ep a rate d an d an a ly z e d f o r t es t i te m c on c en t r at i o n M i c e / R a t s ( N = 3 / g r ou p ) p.o., i .v. , i.p. , s. c . , i. m . i nfus i o n C m a x , T m a x , A U C , c l e a r anc e , t e r m ina l e li m in a tion ha l f li f e , bioa v a il ia b i li t y a n d v olu m e of dist r i buti o n W i n N on l i n Soft w ar e 60 0 0 0 50 0 0 0 40 0 0 0 30 0 0 0 20 0 0 0 10 0 0 0 0 T i ss u e d i s t r i b u t i o n p r o file o f th e T e s t c om pou n d in W ist a r Ra t s BBB - CSF s tud y o f T e s t c o m p o un d in S D Ra t s ( 1 0 mg/ k g ) f o ll ow i n g o r a l 750 P r o d r u g 500 250 D r u g u e a k g f ollo w in g o r a l a d m ini s tr 0 0 0 . 1 0 . 2 T i m e ( h r) 0 . 3 B i oa v ailabili t y of Te s t co m po u n d i n ma l e SD Ra t s a f t er i ntrav e nou s ( 1 mg / k g) a nd o r al (5 m g /k g) a d m i n i s t r ati o n. Ph a r m a c o k in e t i c p r ofile of P rod r ug an d P are n t co m p o un d i n b loo d i n m a l e W i s t ar Rats a f te r i n tr a por t al a d m i n i s t r ati o n of P r od r u g ( 3 m g/ k g) A b o u t G V K B IO GV K Bi o s c i en c e s ( GVK B I O ) i s As i a ’ s l e a d i n g D i sc o v ery Re s e a rc h and De v e l op m ent orga n iz at i on. G V K BIO pr o v i d e s a broa d s pe c trum of s e rv i c e s , s t a n d - a l o ne and i nt egrated, a cr os s t h e R & D va l u e c h a i n. Che mi s t r y S er v ic e s ▪ P ro c es s R & D and Cu s t o m S ynt h e sis ▪ Bi o l o g y ▪ I n f ormat i c s ▪ C l i n ic al Re s e arch ▪ Cl i nic a l Pharma c o l ogy Cont ac t: bd b i o @ gv k b i o. c om V i s i t: www. g v k b i o. c om

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