mobile technologies: riding the hype cycle together

Information about mobile technologies: riding the hype cycle together

Published on June 13, 2016

Author: BrianMBot

Source: slideshare.net

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1. brian m. bot | principal scientist | 2016 june 06 sage bionetworks ohsu oncology retreat mobile technologies: riding the hype cycle together

2. sage bionetworks

3. sage bionetworks promote open systems, incentives, and norms to redefine how complex biological data is gathered, shared, and used our approach

4. sage bionetworks engage diverse communities of researchers around biological and analytical problems too complex for a single institution our focus empower citizens to track their own health and contribute deep phenotypic data to research topics important to them

5. CRC Subtyping Consortium DREAM Challenges Progenitor Cell Biology Consortium TCGA Pan-Cancer Consortium CommonMind Consortium PsychENCODE Accelerating Medicines Partnership Resilience Project M2OVE-AD Consortium Dengue Fever LINCS project Oncology Molecular Classifiers Next Gen Scientific Publishing Mozilla Science Labs sage bionetworks

6. public / private partnership between NIH, 10 biopharmaceutical companies and several non-profit organizations Accelerating Medicines Partnership

7. ($ Millions) Total Project Total NIH Total Industry Alzheimer’s Disease 129.5 67.6 61.9 Type 2 Diabetes 58.4 30.4 28 Rheumatoid Arthritis 41.6 20.9 20.7 TOTAL 229.5 118.9 110.6 Accelerating Medicines Partnership

8. Target Discovery Target Discovery Target Discovery Target Discovery Target Validation Target Validation Target Validation Target Validation Shared Information for Target Identification coordinate sharing of early-phase target identification insights Accelerating Medicines Partnership

9. AMP-AD Collaborative Workspace Quarterly Depositions Broad/ RUSH Mt. Sinai U Fl/ ISB/ Mayo Emory Sage Other Partners Individual Partner Workspaces AMP-AD Data Portal Consortium Space Public space AMP-AD Synapse Project Structure Accelerating Medicines Partnership

10. CRC Subtyping Consortium DREAM Challenges Progenitor Cell Biology Consortium TCGA Pan-Cancer Consortium CommonMind Consortium PsychENCODE Accelerating Medicines Partnership Resilience Project Dengue Fever LINCS project Oncology Molecular Classifiers Next Gen Scientific Publishing Mozilla Science Labs sage bionetworks M2OVE-AD Consortium

11. analysis of: 12 tumor types 6 molecular profiling platforms TCGA Pan-Cancer Consortium

12. 18NPG papers 68core projects 248researchers 28institutions 1070datasets 1723results TCGA Pan-Cancer Consortium

13. TCGA Pan-Cancer Consortium

14. CRC Subtyping Consortium DREAM Challenges Progenitor Cell Biology Consortium TCGA Pan-Cancer Consortium CommonMind Consortium PsychENCODE Accelerating Medicines Partnership Resilience Project Dengue Fever LINCS project Oncology Molecular Classifiers Next Gen Scientific Publishing Mozilla Science Labs sage bionetworks M2OVE-AD Consortium

15. CRC Subtyping Consortium

16. A B C D E F 1 2 3 4 5 6 expert team data subtype CRC Subtyping Consortium

17. A B C D E F 1 2 3 4 5 6 ... expert team data subtype CRC Subtyping Consortium

18. doi:10.1038/nm.3967 doi:10.7303/syn2623706 CRC Subtyping Consortium

19. sage bionetworks engage diverse communities of researchers around biological and analytical problems too complex for a single institution our focus empower citizens to track their own health and contribute deep phenotypic data to research topics important to them

20. Healthmobile

21. Healthm

22. move beyond insular health tracking

23. move beyond insular health tracking nearly 200 million smart phone users in US

24. >75%

25. how to balance desire to share w/ importance of privacy?

26. 2013 september

27. 2015 march

28. the hype cycle

29. the hype cyclelaunching

30. participant-centered consent

31. changeable by participant

32. ~75k participants across all studies >70% opted to share broadly

33. 36 mPower

34. passive measures gps - displacement vectors gps - displacement vectors - - structured activities tapping activity walking/ standing activity voice activity memory game surveys MDS-UPDRS PDQ8 MDS-UPDRS PDQ8 MDS-UPDRS PDQ8 MDS-UPDRS PDQ8 four symptoms of PD motor initiation gait/balance hypophonia memory

35. motor initiation gait/balance hypophonia memory mPower activities

36. x y z userAcceleration gravity rotationRate attitude device motion readings at 100 hz gait / balance

37. gait / balance

38. Monty Python's The Flying Circus gait / balance

39. mPower six month data release 9,520 unique participants 8,320 completed at least one task 198,639 total activities and surveys completed 1,087 self reported parkinson diagnosis

40. mPower six month data release task name type of task and schedule unique participants unique tasks demographics survey - once 6,805 6,805 MDS-UPDRS survey - monthly 2,024 2,305 PDQ8 survey - monthly 1,334 1,641 memory activity - t.i.d. 968 8,569 tapping activity - t.i.d. 8,003 78,887 voice activity - t.i.d. 5,826 65,022 walking activity - t.i.d. 3,101 35,410

41. mHealth research communityParkinson

42. mHealth research communityParkinson

43. Parkinson’s Disease Foundation Eli Lilly AstraZeneca Apple Verily Intel Infocepts Posit Science MIT The Ohio State University University of Otago University of Texas Health Science Center Istanbul Sehir University University of Iowa University of Virginia University of Toronto Johns Hopkins University Vanderbilt University University of Rochester McGill University Xi'an Jiaotong University University of Washington Harvard University mHealth research communityParkinson

44. leverage publicly available data incorporate modules into phase I clinical trial w/ custom scheduling initial training / testing done in person follow ups done remotely by participants mHealth research communityParkinson

45. mHealth research community

46. riding the hype cycle together

47. brian m. bot ———————— principal scientist community manager [email protected] @BrianMBot thank you sage bionetworks

48. Parkinson mHealth research community

49. Parkinson mHealth research community

50. Parkinson mHealth research community

51. Parkinson mHealth research community

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