Scherrer

Information about Scherrer

Published on August 11, 2007

Author: Flemel

Source: authorstream.com

Content

Smoking in Offspring of Alcoholic Twins :  Jeffrey F. Scherrer (1,2); Hong Xian (2); Andrew C. Heath (1,2); Theodore Jacob (1); William R. True (1,3), Kathleen K. Bucholz (1,2) Smoking in Offspring of Alcoholic Twins 1 2 3 BACKGROUND:  BACKGROUND Genes contribute to the transmission of nicotine and alcohol dependence in families Genetic influence on nicotine and alcohol dependence overlap Nicotine dependence is more common in subjects with history of alcohol dependence Parents influence smoking in young adults OBJECTIVE:  OBJECTIVE Characterize smoking in offspring of twins with history of alcohol dependence Characterize smoking in twin generation Determine risk for young adult smoking behaviors as a function of father-child closeness in a design that accounts for the genetic risk imparted from paternal nicotine dependence and alcohol dependence METHODS:  METHODS Sample derived from Children of Alcoholics study (1999-present) Fathers 1464 twin fathers sampled from the Vietnam Era Twin Registry All had at least 1 child 12-26 yrs old in 1999 Twin pairs either concordant or discordant for alcohol dependence. Controls were non-alcoholic twin pairs 1,213 (83%) fathers responded to diagnostic telephone interview Mothers 1,064 biological and/or rearing mothers were eligible 862 (81%) eligible mothers responded to diagnostic telephone interview Offspring 1,487 offspring with consent from both parents were eligible 1,270 (85%) eligible offspring responded to diagnostic telephone interview Measurements:  Measurements Twin father report lifetime nicotine dependence lifetime alcohol dependence Offspring report father-child closeness Age Gender Offspring smoking measures:  Offspring smoking measures Ever try cigarettes Age onset try smoking Regular smoking (Smoke andgt; 100 cigs) Quit/reduce smoking Age quit smoking Failed cessation Years smoked Mean cigarettes in typical day Nicotine withdrawal DSM-IV criteria nicotine dependence Analytic Approach:  Analytic Approach Independent variables: paternal nicotine dependence, paternal alcohol abuse/dependence included to account for sampling design and to control for genes common to ND, offspring age and parent-child closeness Dependent variables: smoking initiation, regular smoking, 1 pls nicotine dependence symptom, DSM-IV nicotine dependence, quit attempt, successful cessation Logistic Regression STATA used to account for clustered data when computing 95% confidence intervals Twin 4 group risk design:  Twin 4 group risk design Grp 1: MZ and DZ twins with ND, high genetic/ high environmental risk Grp 2: MZ with no-ND, co-twin with ND, high genetic/ low environment Grp 3: DZ with no-ND, co-twin with ND, medium genetic/ low environment Grp 4: MZ and DZ twins with no ND, low genetic/ low environment RESULTS:  RESULTS TABLE 1:  TABLE 1 THIS SLIDE FROM WORDPERFECT TABLE 2:  TABLE 2 This slide from wordperfect Slide12:  Slide13:  Slide14:  CONCLUSIONS:  CONCLUSIONS Smoking histories, quit attempts and ND are more common in offspring 18 years or older Smoking is present in non-ND fathers but seems to not increase risk in offspring Offspring at high genetic and high environmental risk were more likely to try cigarettes, become regular smoking, have 1 ND sx, have DSM-IV ND and were less likely to successfully quit Father – child closeness was protective for offspring smoking behaviors.

Related presentations


Other presentations created by Flemel

What is a Play
17. 10. 2007
0 views

What is a Play

Jeopardy HIV STD HPV
06. 08. 2007
0 views

Jeopardy HIV STD HPV

Training School Bus Driver
17. 09. 2007
0 views

Training School Bus Driver

semantics
17. 09. 2007
0 views

semantics

philosophy
27. 09. 2007
0 views

philosophy

como rezar rosario
01. 10. 2007
0 views

como rezar rosario

WorldMuslimCongress Mecca
02. 10. 2007
0 views

WorldMuslimCongress Mecca

sentence
03. 10. 2007
0 views

sentence

DHL presentation
11. 10. 2007
0 views

DHL presentation

VIPAR Presentation
15. 10. 2007
0 views

VIPAR Presentation

annee2005
16. 10. 2007
0 views

annee2005

PrÃsentation JBaer 20avr
17. 10. 2007
0 views

PrÃsentation JBaer 20avr

Panel 17 8 Taking the Pulse
17. 10. 2007
0 views

Panel 17 8 Taking the Pulse

tom eddy
17. 09. 2007
0 views

tom eddy

grass
22. 10. 2007
0 views

grass

CXPBrasil June2005
26. 11. 2007
0 views

CXPBrasil June2005

Theor Astrophysics
29. 11. 2007
0 views

Theor Astrophysics

Carnival Brasil
30. 11. 2007
0 views

Carnival Brasil

boon
26. 10. 2007
0 views

boon

kumar eng
26. 10. 2007
0 views

kumar eng

talking freight
07. 11. 2007
0 views

talking freight

LHC Net meet 101205ppt
28. 09. 2007
0 views

LHC Net meet 101205ppt

cmd04 VW
16. 11. 2007
0 views

cmd04 VW

11 OrgsSimAndReal
22. 11. 2007
0 views

11 OrgsSimAndReal

PolComm1
08. 10. 2007
0 views

PolComm1

CAFTA training
03. 01. 2008
0 views

CAFTA training

2 casting forming
04. 01. 2008
0 views

2 casting forming

Sales Training II Final
11. 08. 2007
0 views

Sales Training II Final

Sonnet
11. 08. 2007
0 views

Sonnet

sommers rev oct 19 ppt
11. 08. 2007
0 views

sommers rev oct 19 ppt

Topic 12 Genetic Disorders 3
11. 08. 2007
0 views

Topic 12 Genetic Disorders 3

Sonnet MLA
11. 08. 2007
0 views

Sonnet MLA

Autism AHistory
05. 01. 2008
0 views

Autism AHistory

Shortage of Girls in China
11. 08. 2007
0 views

Shortage of Girls in China

3 BasicRepro2
07. 12. 2007
0 views

3 BasicRepro2

How Adults Learn
06. 08. 2007
0 views

How Adults Learn

Introversion Turned Inside Out
06. 08. 2007
0 views

Introversion Turned Inside Out

Jenkins
06. 08. 2007
0 views

Jenkins

HCR 107 Overheads
06. 08. 2007
0 views

HCR 107 Overheads

N REG SANIT INT
22. 10. 2007
0 views

N REG SANIT INT

022 Hexapods for robot soccer
31. 12. 2007
0 views

022 Hexapods for robot soccer

Sung Su Truss Bridge
01. 01. 2008
0 views

Sung Su Truss Bridge

Slides KateSteinbeck
11. 08. 2007
0 views

Slides KateSteinbeck

Senate Hearing 2000
11. 08. 2007
0 views

Senate Hearing 2000

William Graham
23. 11. 2007
0 views

William Graham

truman7
29. 12. 2007
0 views

truman7

231nm02
29. 09. 2007
0 views

231nm02

chpt 1 ppt
24. 02. 2008
0 views

chpt 1 ppt

HIV AIDS in Europe
06. 08. 2007
0 views

HIV AIDS in Europe

Heidtke
29. 02. 2008
0 views

Heidtke

NIBSSep021
28. 12. 2007
0 views

NIBSSep021

07 Uae Profilers in TRMM GV Gage
17. 09. 2007
0 views

07 Uae Profilers in TRMM GV Gage

Protista
26. 03. 2008
0 views

Protista

original
07. 04. 2008
0 views

original

slides prog 71
11. 08. 2007
0 views

slides prog 71

wb english
27. 03. 2008
0 views

wb english

Malaria Blue Sky Final Slideshow
30. 03. 2008
0 views

Malaria Blue Sky Final Slideshow

Session1 Parenteau
10. 04. 2008
0 views

Session1 Parenteau

BS3008w1
13. 04. 2008
0 views

BS3008w1

healthcare
06. 08. 2007
0 views

healthcare

SRM Presentation Jim Hanco
14. 04. 2008
0 views

SRM Presentation Jim Hanco

finnews284 2
16. 04. 2008
0 views

finnews284 2

FX Hedging Strategies1
17. 04. 2008
0 views

FX Hedging Strategies1

ioko times showreel
22. 04. 2008
0 views

ioko times showreel

23 Practice Problems
07. 11. 2007
0 views

23 Practice Problems

PE2 U6 R
14. 02. 2008
0 views

PE2 U6 R

ASUD
18. 06. 2007
0 views

ASUD

armi leggere
18. 06. 2007
0 views

armi leggere

apq
18. 06. 2007
0 views

apq

apicorso
18. 06. 2007
0 views

apicorso

aeipres
18. 06. 2007
0 views

aeipres

901059 Kids Share ppt
18. 06. 2007
0 views

901059 Kids Share ppt

Sporting tips
18. 06. 2007
0 views

Sporting tips

semi2
18. 06. 2007
0 views

semi2

Saker Motorports USALLC
18. 06. 2007
0 views

Saker Motorports USALLC

Running on Fumes
18. 06. 2007
0 views

Running on Fumes

FBranca Luxembourg 3mar
26. 11. 2007
0 views

FBranca Luxembourg 3mar

Sisvalsoc
18. 06. 2007
0 views

Sisvalsoc

Shalom Auschwitz Ginocchio
18. 06. 2007
0 views

Shalom Auschwitz Ginocchio

scrittura
18. 06. 2007
0 views

scrittura

scheda unipol
18. 06. 2007
0 views

scheda unipol

satzherstellung
18. 06. 2007
0 views

satzherstellung

uss presentation
02. 01. 2008
0 views

uss presentation

HandsOnWMS nov
16. 10. 2007
0 views

HandsOnWMS nov

hatikvah E2 short
22. 10. 2007
0 views

hatikvah E2 short

amer deadlocks
17. 09. 2007
0 views

amer deadlocks

deadlocks
17. 09. 2007
0 views

deadlocks

L14 Deadlock
17. 09. 2007
0 views

L14 Deadlock

Chapter 03
17. 09. 2007
0 views

Chapter 03

Slides Egidi
18. 06. 2007
0 views

Slides Egidi

Ballanti Diagramaps 070704
18. 06. 2007
0 views

Ballanti Diagramaps 070704

1111 123080220071234
24. 10. 2007
0 views

1111 123080220071234

Dr Tom Sparrow
17. 09. 2007
0 views

Dr Tom Sparrow

amiland gesetze
18. 06. 2007
0 views

amiland gesetze

Gen Micro130 ch1
16. 10. 2007
0 views

Gen Micro130 ch1

bus safety
15. 06. 2007
0 views

bus safety

xo Overheads 2
15. 06. 2007
0 views

xo Overheads 2

Wandering
15. 06. 2007
0 views

Wandering

walker ssm
15. 06. 2007
0 views

walker ssm

spelling
15. 06. 2007
0 views

spelling

spanish american humor
15. 06. 2007
0 views

spanish american humor

research paper checklist
15. 06. 2007
0 views

research paper checklist

Phil Logic 2000 1
15. 06. 2007
0 views

Phil Logic 2000 1

merchant
15. 06. 2007
0 views

merchant

Love 3
15. 06. 2007
0 views

Love 3

jewish humor
15. 06. 2007
0 views

jewish humor

oef 9 opl
15. 06. 2007
0 views

oef 9 opl

oef 2 opl
15. 06. 2007
0 views

oef 2 opl

obscenity andc ensorship
15. 06. 2007
0 views

obscenity andc ensorship

intro to personality psych
06. 08. 2007
0 views

intro to personality psych

Neorev
24. 02. 2008
0 views

Neorev

session 3b cogdell
18. 06. 2007
0 views

session 3b cogdell

jurors
06. 08. 2007
0 views

jurors

Hyde
06. 08. 2007
0 views

Hyde

Reunion Burgos
18. 06. 2007
0 views

Reunion Burgos

JSOBasic
06. 08. 2007
0 views

JSOBasic

sipf050405ih
23. 10. 2007
0 views

sipf050405ih

419 banks 051
10. 03. 2008
0 views

419 banks 051

pries vortraege
14. 11. 2007
0 views

pries vortraege

scar slides
17. 11. 2007
0 views

scar slides

Item 2 Mercury in Terns
06. 08. 2007
0 views

Item 2 Mercury in Terns

The new obesity guidance
11. 08. 2007
0 views

The new obesity guidance

Socrates IIa
11. 08. 2007
0 views

Socrates IIa

ID3 MedhaPradhan
26. 10. 2007
0 views

ID3 MedhaPradhan

AeroSpace Workshop JK mods
22. 10. 2007
0 views

AeroSpace Workshop JK mods

tritroph
30. 12. 2007
0 views

tritroph

Trick or Treaters
18. 06. 2007
0 views

Trick or Treaters

Saviez vous que
11. 08. 2007
0 views

Saviez vous que