SUPPOSITORIES PPT

Information about SUPPOSITORIES PPT

Published on November 15, 2008

Author: amitmgupta31

Source: authorstream.com

Content

Slide 1: 1 SUPPOSITORIES Amit M . Gupta, Lecturer, Agnihotri College Of Pharmacy, Wardha (M.S) Slide 2: 2 A SUPPOSITORY IS A MEDICATED SOLID DOSAGE FORM GENERALLY INTENDED FOR USE IN RECTUM, VAGINA AND TO A LESSER EXTENT IN URETHRA. VAGINAL SUPPOSITORIES ARE ALSO KNOWN AS PESSARIES. SUPPOSITORY Slide 3: 3 Slide 4: 4 Slide 5: 5 Slide 6: 6 DRUGS HAVING LOCAL AND SYSTEMIC EFFECT CAN BE ADMINISTERED. PROSTAGLANDIN –CONTAINING VAGINAL SUPPOSIT--ORIES FOR INTRUPTION OF EARLY PREGNANCY TREATMENT OF CONSTIPATION AND HEMORRHOIDS. USE FOR SYSTEMIC EFFECT WHEN ORAL MEDICATI- -ON WOULD NOT BE RETAINED OR ABSORB PROPERLY SUCH AS IN NAUSEA & VOMITING USES Slide 7: 7 Absorption Slide 8: 8 Rectum Absorption Terminal 15-19 cm of large intestine (LI) Rectal Fluids -> no buffering capacity – 1. 2 - 3 mL – pH 6.8 – Mild environment / drug can change pH – LI function absorb H2O and electrolytes Low S area -> poor absorption compare SI – Rectum usually empty of feces Slide 9: 9 Slide 10: 10 Rectal Blood Circulation Main blood supply superior rectal artery Blood return 3 blood veins – Superior hemorrhoidal vein – Middle hemorrhoidal vein – Inferior hemorrhoidal vein Slide 11: 11 Slide 12: 12 Slide 13: 13 Vagina ABSORPTION Fibromuscular tub about - 7.5 cm long Vaginal Blood Circulation – Blood supply vaginal artery (branch of iliac) – Blood return avoids the hepatic portal system Typically targeted drug administration Vaginal fluids – Origin in cervix – Protective mucus Complex mixture of proteins and polysaccharides – Low pH 3 <- (3.5 - 4.2) -> 6 – Prepuberal & post-menopause neutral to slightly alkaline Slide 14: 14 Urethra Absorption Tube – Males 20 cm – females 4 cm Poorly perfused by blood Slide 15: 15 Slide 16: 16 Slide 17: 17 Slide 18: 18 Slide 19: 19 Slide 20: 20 Slide 21: 21 Slide 22: 22 Slide 23: 23 Slide 24: 24 SUPPOSITORIES BASES THEY ACT AS A VEHICAL FOR MEDICAMENTS Slide 25: 25 Slide 26: 26 NON-TOXIC HAS NO METASTABLE FORM NON-SENSITIZING WETTING & EMULSIFYING PROPERTY IT CAN BE MANUFACTURED BY MOULDIGNG BY HAND OR BY MACHINE,COMPERATION Slide 27: 27 IF THE BASE IS FATTY THEN ACID VALUE IS BELOW 0.2 SAPONIFICATION VALUE RANGES FROM 200 – 245 IODINE VALUE IS LESS THAN 7 THE INTERVAL BETWEEN MELTING POINT & SOLIDIFICATION POINT IS SMALL Slide 28: 28 Slide 29: 29 Slide 30: 30 Slide 31: 31 Slide 32: 32 Slide 33: 33 Slide 34: 34 Slide 35: 35 Slide 36: 36 Slide 37: 37 Slide 38: 38 Slide 39: 39 Slide 40: 40 Slide 41: 41 Slide 42: 42 Slide 43: 43 Slide 44: 44 Slide 45: 45 Slide 46: 46 Slide 47: 47 Slide 48: 48 Slide 49: 49 AUTOMATIC MOLDING MACHINE POURING COOLING REMOVAL PAKAGING Slide 50: 50 PACKAGING OF MOLDED SUPPOSITORIES IN PACKAGE Slide 51: 51 APROCHES OF FORMULATING SUPPOSITORIES LOCAL & SYSTEMIC USE APPLICATION FOR VAGINA,RECTAL & URETHRAL QUICK & PROLONG ACTION Slide 52: 52 SPECIFIC PROBLEMS IN FORMULATING WATER IN SUPPOSITORIES HYGROSOPICITY INCOMPATIBILITY VISCOSITY BRITTELNESS Slide 53: 53 DENSITY VOLUME CONTRACTION LUBRICANTS DOSES REPLACEMENT FACTOR f=100(E-G) / (G)(X) + 1 Slide 54: 54 WEIGHT & VOLUME CONTROL RANCIDITY & ANTIOXIDANTS Slide 55: 55 TESTING OF SUPPOSITORIES MELTING RANGE TEST SOFTENING TIME TEST OF RECTAL SUPPOSITORIES BREAKING TEST DISSOLUTION TEST Slide 56: 56 }{ !! THANK YOU!! }{ Slide 57: 57 Slide 58: 58

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