virosomesas adjuvants for antigendelivery

Information about virosomesas adjuvants for antigendelivery

Published on August 7, 2014

Author: deepthikolluru

Source: authorstream.com

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VIROSOMES ADJUVANTS FOR ANTIGEN DELIVERY & LICENSED VIROSOMAL VACCINES: VIROSOMES ADJUVANTS FOR ANTIGEN DELIVERY & LICENSED VIROSOMAL VACCINES K.L.DEEPTHI M.PHARM Asst. Prof. Sri Venkateswara College of Pharmacy, Etcherla vaccines: vaccines Live, replicating, vaccines have the advantage that they closely mimic the actual infection and therefore induce a broad and physiologically relevant immune response: Humoral immune response (antibody production) Cell-mediated immunity ( cytotoxic T lymphocytes). Disadvantage: Replication of antigens 11/07/2014 2 s.v.college of pharmacy, etcherla Vaccine adjuvants: Vaccine adjuvants The most commonly used and approved adjuvants for human use are Aluminium Salt Derivatives Adverse reactions: irritation and inflammation at the injection site. A new generation vaccines is needed capable of inducing a strong specific immune response and possessing a more favorable safety profile than the classical preparations. 11/07/2014 3 s.v.college of pharmacy, etcherla virosomes: virosomes v Virosomes are virus-like particles consisting reconstituted viral envelope lacking the viral genetic material. 11/07/2014 4 s.v.college of pharmacy, etcherla Virosomes as adjuvant : Virosomes as adjuvant Structuraleffects repetitively arrayed antigen protection of antigen appetizer-sized particle HA-mediated effects targeting of immune cells fusion: access to MHC I&II co- immuno stimulation(CD4) 11/07/2014 5 s.v.college of pharmacy, etcherla Virosome components: Virosome components HA- glycoprotein of influenza virus mediates the fusion process. Phospholipids consist of 70% lecithin, a structural component, 20% cephalin . 11/07/2014 6 s.v.college of pharmacy, etcherla preparation method: Lyophilization of Virosomes: preparation method: Lyophilization of Virosomes 11/07/2014 7 s.v.college of pharmacy, etcherla preparation: preparation 11/07/2014 8 s.v.college of pharmacy, etcherla Function of virosomes: Function of virosomes 11/07/2014 9 s.v.college of pharmacy, etcherla Function of virosomes: Function of virosomes 11/07/2014 10 s.v.college of pharmacy, etcherla Licensed virosomal vaccines crucell -- US Patent No.5, 683, 866 ---F-VIROSOMES Pevitertm: HCV Vaccine Phasei : Licensed virosomal vaccines crucell -- US Patent No.5, 683, 866 ---F-VIROSOMES Pe vitertm : HCV Vaccine Phasei INFLUENZA VACCINE ( Five-in-one ) Measles and Rubella Vaccine hepatitis B vaccine Aluminum-free Hepatitis A Vaccine 07/11/2014 11 s.v.college of pharmacy, etcherla Virosomal preparations: Virosomal preparations S. No. Virosomal preparations Application A Virosomes antigen based products 1 1 Hepatitis A virus envelope proteins (EpaxalW) Hepatitis a 2 Influenza virus (InflexalW V) Influenza B Virosomal antigen preparations under clinical trials 1 Diphtheria/tetanus toxoid virus envelope proteins Diphtheria, Tetanus 2 Peptidomimetic of loop I from domain III of Plasmodium falciparum AMA-1 Malaria 3 PEV6 Breast cancer C Virosomal antigen preparations under pre clinical trials 1 Doxorubicin Cancer 2 Doxorubicin Ovarian carcinoma 3 L-myc antisense ODNs Cancer 4 DNA-encoded TAA Prostate Carcinoma 5 DNA-encoded mumps antigen Mumps 6 Melan A/Mart-1 peptides Melanoma 7 RSV F protein RSV 8 Hepatitis C peptides Hepatitis C 9 VSV G protein Vesicular stomatitis 10 NDV envelope proteins disease 11 HIV proteins AIDs 12 PEV4 RSV 13 PEV7 Candida 14 PEV 8 Universal influenza 07/11/2014 12 s.v.college of pharmacy, etcherla conclusion: conclusion A new generation of prophylactic and therapeutic vaccines is needed: vaccines capable of inducing a strong specific immune response and possessing a more favorable safety profile than the classical preparations Virosomes fulfill all the prerequisites necessary to serve as new gold standard adjuvant and carrier system for next generation prophylactic vaccines. 11/07/2014 13 s.v.college of pharmacy, etcherla PowerPoint Presentation: 11/07/2014 14 s.v.college of pharmacy, etcherla bibilography: bibilography Mohd Yasir et al / Int.J . PharmTech Res.2010,2(4) Derek t o,hang,Encycolpedia of life sciences 2007, john willey and sons, ltd www.els.net Mustafeej mujtabar,journal of antivirals and antiretrovirals 2013,5:7 issn 1948 – 5864 Majunder pulak et.al, journal of pharmaceutical and science innovation 1(5), sept – oct 2012, 31 – 35 www.mymetics.com/vaccines/virosomes www.crucell.com/page/.../moser.pdf www.ncbi.nlm.nih.gov/pubmed/17937752 07/11/2014 15 s.v.college of pharmacy, etcherla

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